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It remains unclear how ligand-receptor interaction determines the agonist or antagonist activity of the ligand.

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In contrast, the AR, which is 110 kDa in size, requires help to be actively transported upon ligand binding.

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These are three multicenter, randomized, double-blind, parallel group trials comparing bicalutamide 150 mg daily monotherapy (adjuvant to previous therapy or under watchful waiting) with placebo, for death or time to disease progression, in a population of 8113 patients with localized or locally advanced prostate cancer.

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For example, one small but often-cited study, published in 1999 in the New England Journal of Medicine, found that 77% of men who had prostate cancer with lymph node metastases and chose to undergo hormone therapy were still alive and had no recurrent disease roughly seven years later, as compared with only 18% of men who decided to forgo hormone treatment until the cancer spread to bones or lungs.

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But, one thing for sure is is used for blocking 3-5% of male hormonal effect from adrenal glands.

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However, when mice were treated with S AHA followed by IL-13-PE, a significant decrease in tumor size was observed.

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Although intermittent therapy may rely upon restoring a normal testosterone level, it is believed that the testosterone level should be as low as possible when the patient is on treatment, thus generating the lowest serum PSA level possible and likely improving outcome.

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