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Essentially, the drug increases the sensitivity of calcium-sensing receptors.

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However, the authors recommend that great caution be used when placing any child on a diet with less than the DRI of calcium and that a dietitian be consulted for assistance.

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In the study of anti-resorptive agents over a two-year period, there was a comparison of placebo, estrogen, calcitonin and alendronate.

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Nondrug remedies for milder symptoms also are discussed.

Alendronate is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.

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Inflammatory reactions develop at early stages as part of the resolution process.

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It is probably best known for helping prevent osteoporosis.

Affected children are usually asked to refrain from participation in sports to lessen the risk of fractures.

PubMed literature from January 1, 1998, to May 1, 2008, was reviewed using bisphosphonate and clinical practice as search terms.

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However, pooled analyses showed no differences in occurrence of mild upper gastrointestinal events among alendronate, ibandronate, risedronate, or zoledronic acid versus placebo; however, pooled analyses of 18 trials of etidronate versus placebo indicated an increased risk for mild gastrointestinal events.

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The aim of this meta-analysis was to evaluate the efficacy and safety of two bisphosphonates ( alendronate and zoledronate) in the treatment of postmenopausal osteoporosis.

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In 2006, the same drug was used to treat two patients with brain calcification linked to specific medical conditions: a child with seizures undergoing chemotherapy and exhibiting small spots of calcification and a patient with a cerebral hemangioma with calcifications.

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Many patients (40% in one series) have even noted a loss of stone mass while on orthophosphate therapy.

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Patients have also been treated with anti-secretory agents, antacids, Gaviscon, and sucralfate to reduce exposure of the injured mucosa to refluxed acids.

The other study compared sevelamer with calcium acetate and atorvastatin (as control for the low-density lipoprotein reduction with sevelamer), but there was a very high drop-out rate in both treatment groups.

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs.

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Indeed, histomorphometric analyses of iliac crest biopsy specimens from patients with OI who had received pamidronate therapy demonstrated increased cortical thickness and number of trabeculae but no increase in trabecular thickness.

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Garnero P, Darte C, Delmas PD: A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover.

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Both treatments significantly increased lumbar spine bone density which was the primary outcome of the study.

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